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KMID : 0616120200510030186
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Korean Journal of Pharmacognosy
2020 Volume.51 No. 3 p.186 ~ p.191
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Anti-nociceptive Effects of Sorbus alnifolia
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Kim Bong-Seok
Yun Sun-Hwa
Shin Youn-Chel
Kang Bo-Hye
Park Seung-Ju
Yang Woo-In
Lee Se-Youn
Cha Dong-Seok
Jeon Hoon
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Abstract
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In this study, we evaluated the anti-nociceptive activities of Sorbus alnifolia. To investigate the anti-nociceptive properties of the methanolic extract of Sorbus alnifolia (MSA), we conducted several tests using various experimental mouse pain models. Herein, MSA significantly delayed the latency time and writhing motion in the hotplate test and acetic acid test, respectively. These result indicated that MSA has an ability to manage both peripheral and central nociception. We could further confirm the analgesic effects of MSA by performing formalin test. In combination test using naloxone, a non-selective opioid receptor antagonist, analgesic activity of MSA was partly antagonized by naloxone, but not completely, indicating that the MSA acts as a partial opioid receptor agonist. Out results suggest that the S. alnifolia may be possibly used as valuable anti-nociceptive agent.
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KEYWORD
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Sorbus alnifolia, Anti-nociception, Opioid receptor
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